Presentation
The neurobehavioural platform offers various equipment for the functional analysis of mouse models in vivo. This platform includes a housing room, a stereotaxic injection station and is equipped with a series of rooms for behavioral tests to study learning and memory (Morris Water Maze (MWM), contextual fear conditioning (CFC), object recognition (NOR) or location (NOL)), motor functions (rotarod and bar beam), anxiety-related behaviors (elevated plus maze, open field and dark and light), depression (tail hang test (TST) and forced swim test (FST)); and study of metabolism and physiological parameters using metabolic cage for indirect calorimetry (PhenoMaster TSE system).
Localisation
Imagine - Institut des maladies génétiques - LEAT
24 Boulevard du Montparnasse, 75015 Paris
Staff
Equipement
Morris Water Maze (BIOCONCEPT): This test studies spatial learning and memory.
New object recognition test: This test measures memory and is based on the natural tendency of rodents to preferentially explore a new object over a familiar object.
Object location test: This test is another variation of the new object recognition test, involving spatial memory.
Contextual Fear Conditioning (BIOSEB): This test measures associative memory.
Rotarod (BIOSEB): This test measures motor coordination, balance and fatigue.
Bar Beam (Phymep): This test measures balance and motor coordination.
Elevated Cross Maze (BIOSEB): This test measures anxiety.
The open field test (TSE): This test is most often used to measure general locomotion and anxiety-related behaviors.
The DARK/LIGHT Transition Test (TSE): This test measures anxiety and spontaneous exploratory behaviors in new environments.
The tail suspension test: This test is used to assess the state of depression.
The forced swimming test: This test is used to assess the state of depression.
Phenomaster Metabolic Chamber (TSE) System: This system allows fully automated and perfectly synchronized evaluation of metabolic and physiological parameters with the highest precision.
Stereotaxic frame (Kopf model 940).
Services
Publications
FGFR3 overactivation in the brain is responsible for memory impairment in Crouzon syndrome mouse model. Cornille M*, Moriceau S*, Khonsari RH, Heuzé Y, Loisay L, Boitez V, Morice A, Arnaud E, Collet C, Bensidhoum M, Kaci N, Boddaert N, Paternoster G, Rauschendorfer T, Werner S, Mansour S, Di Rocco F, Oury F, Legeai-Mallet L. Journal of Experimental Medicine. 2022, 219. https://doi.org/10.1084/jem.20201879
Systemic bis‑phosphinic acid derivative restores chloride transport in Cystic Fibrosis mice. Faria da Cunha M, Pranke I, Sassi A, Schreiweiss C, Moriceau S, Vidovic D, Hatton A, Carlon MS, Creste G, Berhal F, Prestat G, Freund R, Cottart CH, Odolczyk N, Jais JP, Gravier-Pelletier C, Zielenkiewicz P, Jullien V, Hinzpeter A, Oury F, Edelman A and Sermet-Gaudelus I. Scientific Report. 2022, 12: 6132 doi.org/10.1038/s41598-022-09678-9
Mechanisms by which autophagy regulates memory capacity in ageing.
De Risi M, Torromino G, Tufano M, Moriceau S, Pignataro A, Rivagorda M, Carrano N, Middei S, Settembre C, Ammassari-Teule M, Gardoni F, Mele A, Oury F, De Leonibus E. Aging Cell. 2020 Sep;19(9):e13189. doi: 10.1111/acel.13189. Epub 2020 Jul 30.PMID: 32729663
Joseph A*, Moriceau S*, Sica V, Anagnostopoulos G, Pol J, Martins I, Lafarge A, Maiuri MC, Leboyer M, Loftus J, Bellivier F, Belzeaux R, Berna F, Etain B, Capdevielle D, Courtet P, Dubertret C, Dubreucq J, Thierry A, Fond G, Gard S, Llorca PM, Mallet J, Misdrahi D, Olié E, Passerieux C, Polosan M, Roux P, Samalin L, Schürhoff F, Schwan R; FACE-SZ and FACE-BD (FondaMental Academic Centers of Expertise, for Schizophrenia and for Bipolar Disorder) Groups, Magnan C, Oury F, Bravo-San Pedro JM, Kroemer G.Cell Death Dis. 2020 Jul 6;11(7):502. doi: 10.1038/s41419-020-2716-5.PMID: 32632162
Fregeac J, Moriceau S, Poli A, Nguyen LS, Oury F, Colleaux L. Mol Autism. 2020 Mar 30;11(1):22. doi: 10.1186/s13229-020-00328-3.PMID: 32228681
Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline.
Glatigny M*, Moriceau S*, Rivagorda M, Ramos-Brossier M, Nascimbeni AC, Lante F, Shanley MR, Boudarene N, Rousseaud A, Friedman AK, Settembre C, Kuperwasser N, Friedlander G, Buisson A, Morel E, Codogno P, Oury F. Curr Biol. 2019 Feb 4;29(3):435-448.e8. doi: 10.1016/j.cub.2018.12.021. Epub 2019 Jan 17.PMID: 30661803
Gpr158 mediates osteocalcin's regulation of cognition.
Khrimian L, Obri A, Ramos-Brossier M, Rousseaud A, Moriceau S, Nicot AS, Mera P, Kosmidis S, Karnavas T, Saudou F, Gao XB, Oury F, Kandel E, Karsenty G. J Exp Med. 2017 Oct 2;214(10):2859-2873. doi: 10.1084/jem.20171320. Epub 2017 Aug 29.PMID: 28851741