The Genome targeting and editing platform aims to provide experimental and technical expertise to researchers interested in performing targeted or genome-wide screens and the generation of cellular and animal models using the CRISPR-Cas9 system. The platform will work directly to:


  • create novel reporter systems

  • optimize relevant strategies

  • design, amplify and package sgRNA libraires

  • assist in reagent and vector generation and creation

  • library sequencing preparation and data analysis

  • incorporate and develop new advances and technologies in the field


We are currently hosting several mouse and human CRISPR inhibition and activation libraries for genome-wide screening:


  • Dolomiti_setA (murine inhibition)

  • Dolcetto_setA (human inhibition)

  • Coprano_setA (murine activation)

  • Calabrese_setA (human activation)

  • Human_v2_Inhibition_top5

  • Human_v2-Activation_top5

  • Mouse_v2_Inhibition_top5


In addition, the platform has a wide variety of targeting constructs to assist in creating custom cellular and animal models (working directly with the Transgenesis Platform).




Faculty of Medicine, University of Paris, Room 618B
160 rue de Vaugirard
75015 Paris, France


tel: +33 (0)1 40 61 53 78


Nicolas Kuperwasser, PhD
Marco Pontoglio-1_edited.jpg
Marco Pontoglio, PhD

Scientific adviser


For year 2022, year of the implementation of the image analysis center, there is no Fees, The fees will be calculated starting from January 2023.